Practical Ethics

Hunger for long life: the ethics of caloric restriction experiments

This has been a good week for life extension research, with the Nature paper Rapamycin fed late in life extends lifespan in genetically heterogeneous mice by Harrison et al. (free News and Views) showing that the drug boosts lifespan in middle aged mice, and Science countering with Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys by Colman et al. showing that in a 20-year longitudinal study rhesus monkeys do seem to benefit from caloric restriction (CR). CR involves keeping the energy intake low, but not so low that it induces starvation.

Not everybody seems to like the experiment. The Swedish major newspaper Dagens Nyheter had an article by Per Snaprud that appeared to criticise the monkey experiment on ethical grounds. He quotes Mats Spångberg, chief veterinarian at the Swedish Institute for Infectious Disease Control, who doubts the experiment would have been approved in Sweden. The only use of monkeys in Swedish research is AIDS vaccine research. The article concludes by stating that the virus kills 2 million people every year, 270,000 of whose are children.

But ageing kills 100,000 people worldwide each day directly or indirectly. 100% of humans and monkeys are "infected".

Sometimes justice wears a mask: blogging, anonymity and the open society

After the Times exposed the identity of the police blogger "Night Jack" he has been disciplined by the police force. The blog (now deleted) had won the Orwell Price for political writing and often expressed critical views related to the police and the justice system. In a court ruling Mr Justice Eady claimed that blogging was "essentially a public rather than a private activity" and that it was in the public interest to know who originated opinions and arguments. Do we have a right to anonymity on the net? And is it truly in the public interest to know who every blogger is?

Not better than the alternative: an informal experimentation tragedy

Police are reinvestigating the 2007 death of Yolanda Cox, a woman who collapsed in anaphylactic shock after being injected with an experimental drug by her sister, a GP. The drug was developed by their mother, originally intended to treat diabetes but apparently believed to extend lifespan. After testing on diabetic patients and apparently themselves without any apparent side effects the mother and sister gave it to the woman three times, with tragic consequences the third time. Was it a failure of medical ethics, research ethics - or plain psychological bias?

Precrime in Camden: using DNA profiles for crime prevention

The UK police has an estimated 5.3 million DNA profiles in its databases, of which about 850,000 are of people who were never convicted of any crime (including 24,000 samples of youngsters who have never been convicted, cautioned or charged with any offence). Although the European Court ruled that a policy of retaining profiles of innocent people is illegal, the Home Office seems keen to retain them anyway, at least for serious crimes. Now it is claimed by a police officer that police in Camden deliberately target young people who have not been arrested yet in order to obtain DNA samples. According to him it is part of a long-term crime prevention strategy to discourage future crime. But does pre-emptive acquisition of DNA profiles make sense as crime prevention?

Shining monkey, sadistic conclusion?

Japanese researchers have genetically modified marmoset monkeys, and demonstrated that the modification can be inherited by their offspring. The modification was the standard green fluorescent protein making the monkey's glow green under UV light, a marker to demonstrate that the modification worked (BBC shows a picture of their feet glowing "an eerie green", while the picture in Nature's News and Views shows the cute monkeys in normal light and the original paper shows both). The long-term aim is to be able to produce transgenic primates that could act as disease models for humans - many conditions do not map well onto mice and rats. But is it acceptable to introduce heritable illness conditions into animals?

Biting into the sour apple: liberal society, abortion rights and sex selection

The Swedish National Board of Health and Welfare has recently declared that it is impossible to deny abortions to women who base their decision on the sex of the foetus. This ruling came about after a case where a woman twice aborted foetuses because they were female. This upset not only the medical personnel, but also social minister Göran Hägglund who declared that it was horrible that people valued sexes differently. But while the majority of Swedes probably do think sex selection is immoral, the right to free abortion is equally strongly held. This poses an interesting problem for socially and politically liberal societies like Sweden: allow gender selection, or try to restrict abortion?

The flu paradox: is the WHO focusing too little on flu?

The WHO is in the news these days thanks to the H1N1 epidemic (alias the swine flu, or the Colbert flu), and it is doing an admirable job coordinating various national agencies in fighting a pandemic. Historically it has been at the forefront of fighting epidemic disease, whether tuberculosis or AIDS. However, since Gro Harlem Brundtland's director-generalship 1998-2003 there has been an increased emphasis on public health, in particular fighting alcohol and tobacco use but also traffic accidents. Has the WHO aimed at the right or wrong problems?

Intuitive pirates: why do we accept file sharing so much?

Piracy is in the headlines, whether in Somalian waters or Swedish cyberspace. A Stockholm court this friday found four men guilty of promoting copyright infringement by running the popular file-sharing site The Pirate Bay and sentenced them to one year in prison as well as a 30 million kronor fine (about $3.5 million). The case will no doubt go to a higher court and the circus (as well as the piracy) will continue. Legally, at least in the sense of the spirit of the laws banning copyright infringement, the case is pretty clear. But morally, what is wrong with file sharing? And why don't people care?

Be mindful of results, not the method

David King warns that we should modify society, not childrens' brains. This is a response to a recent Radio 4 documentary on "the criminal mind", which discussed recent evidence for biological underpinnings of some forms of antisocial behaviour and the possibility of reducing it using vitamins, drugs or early interventions. Dr King quite rightly points out that the image given by the program tends to oversimplify things and promote a reductionistic view of the causes of crime. But he also appears to contend that complex social problems cannot be solved through biological interventions. In this he is likely wrong.

Ecclesiastical gaydar: should churches be allowed to discriminate priests?

Melbourne's Catholic Churches have decided to test potential priests for sexual orientation, banning those that appear to be gay. This is in accordance with the Vatican recommendation that even celibate gays should not be allowed in the priesthood. Needless to say, both people within and outside the church have reacted negatively to it. But to what extent can a church declare who is fit to hold positions in it? And would the testing be fair?